1p0q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1p0q.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1p0q.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1p0q| PDB=1p0q | SCENE= }}
{{STRUCTURE_1p0q| PDB=1p0q | SCENE= }}
-
'''Crystal structure of soman-aged human butyryl cholinesterase'''
+
===Crystal structure of soman-aged human butyryl cholinesterase===
-
==Overview==
+
<!--
-
Cholinesterases are among the most efficient enzymes known. They are divided into two groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, and butyrylcholinesterase of unknown function. Several crystal structures of the former have shown that the active site is located at the bottom of a deep and narrow gorge, raising the question of how substrate and products enter and leave. Human butyrylcholinesterase (BChE) has attracted attention because it can hydrolyze toxic esters such as cocaine or scavenge organophosphorus pesticides and nerve agents. Here we report the crystal structures of several recombinant truncated human BChE complexes and conjugates and provide a description for mechanistically relevant non-productive substrate and product binding. As expected, the structure of BChE is similar to a previously published theoretical model of this enzyme and to the structure of Torpedo acetylcholinesterase. The main difference between the experimentally determined BChE structure and its model is found at the acyl binding pocket that is significantly bigger than expected. An electron density peak close to the catalytic Ser(198) has been modeled as bound butyrate.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12869558}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12869558 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12869558}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Serine hydrolase]]
[[Category: Serine hydrolase]]
[[Category: Soman]]
[[Category: Soman]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:32:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:48:29 2008''

Revision as of 02:48, 29 July 2008

Image:1p0q.png

Template:STRUCTURE 1p0q

Crystal structure of soman-aged human butyryl cholinesterase

Template:ABSTRACT PUBMED 12869558

About this Structure

1P0Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products., Nicolet Y, Lockridge O, Masson P, Fontecilla-Camps JC, Nachon F, J Biol Chem. 2003 Oct 17;278(42):41141-7. Epub 2003 Jul 17. PMID:12869558

Page seeded by OCA on Tue Jul 29 05:48:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1p0q"
Personal tools