1r1f

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{{STRUCTURE_1r1f| PDB=1r1f | SCENE= }}
{{STRUCTURE_1r1f| PDB=1r1f | SCENE= }}
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'''Solution Structure of the Cyclotide Palicourein: Implications for the development of pharmaceutical and agricultural applications'''
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===Solution Structure of the Cyclotide Palicourein: Implications for the development of pharmaceutical and agricultural applications===
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==Overview==
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The cyclotides are a family of disulfide-rich proteins from plants. They have the characteristic structural features of a circular protein backbone and a knotted arrangement of disulfide bonds. Structural and biochemical studies of the cyclotides suggest that their unique physiological stability can be loaned to bioactive peptide fragments for pharmaceutical and agricultural development. In particular, the cyclotides incorporate a number of solvent-exposed loops that are potentially suitable for epitope grafting applications. Here, we determine the structure of the largest known cyclotide, palicourein, which has an atypical size and composition within one of the surface-exposed loops. The structural data show that an increase in size of a palicourein loop does not perturb the core fold, to which the thermodynamic and chemical stability has been attributed. The cyclotide core fold, thus, can in principle be used as a framework for the development of useful pharmaceutical and agricultural bioactivities.
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{{ABSTRACT_PUBMED_14725768}}
==About this Structure==
==About this Structure==
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1R1F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Palicourea_condensata Palicourea condensata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1F OCA].
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1R1F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Palicourea_condensata Palicourea condensata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1F OCA].
==Reference==
==Reference==
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[[Category: Cyclotide]]
[[Category: Cyclotide]]
[[Category: Palicourein]]
[[Category: Palicourein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:57:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:49:35 2008''

Revision as of 02:49, 29 July 2008

Image:1r1f.png

Template:STRUCTURE 1r1f

Solution Structure of the Cyclotide Palicourein: Implications for the development of pharmaceutical and agricultural applications

Template:ABSTRACT PUBMED 14725768

About this Structure

1R1F is a Single protein structure of sequence from Palicourea condensata. Full experimental information is available from OCA.

Reference

Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework., Barry DG, Daly NL, Bokesch HR, Gustafson KR, Craik DJ, Structure. 2004 Jan;12(1):85-94. PMID:14725768

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