2jmc

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[[Image:2jmc.gif|left|200px]]
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{{Seed}}
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[[Image:2jmc.png|left|200px]]
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{{STRUCTURE_2jmc| PDB=2jmc | SCENE= }}
{{STRUCTURE_2jmc| PDB=2jmc | SCENE= }}
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'''Chimer between Spc-SH3 and P41'''
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===Chimer between Spc-SH3 and P41===
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==Overview==
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Here we present the high-resolution NMR structure of a chimera (SPCp41) between alpha-spectrin SH3 domain and the decapeptide p41. The tertiary structure mimics perfectly the interactions typically found in SH3-peptide complexes and is remarkably similar to that of the complex between the separate Spc-SH3 domain and ligand p41. Relaxation data confirm the tight binding between the ligand and SH3 part of the chimera. This chimera will serve as a tool for a deeper understanding of the relationship between structure and thermodynamics of binding using a combination of NMR, stability and site-directed mutagenesis studies, which can lead to an effective strategy for ligand design.
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The line below this paragraph, {{ABSTRACT_PUBMED_17275816}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17275816 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17275816}}
==About this Structure==
==About this Structure==
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2JMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMC OCA].
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2JMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMC OCA].
==Reference==
==Reference==
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[[Category: P41]]
[[Category: P41]]
[[Category: Spc-sh3]]
[[Category: Spc-sh3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:01:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:51:11 2008''

Revision as of 02:51, 29 July 2008

Image:2jmc.png

Template:STRUCTURE 2jmc

Chimer between Spc-SH3 and P41

Template:ABSTRACT PUBMED 17275816

About this Structure

2JMC is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

The high-resolution NMR structure of a single-chain chimeric protein mimicking a SH3-peptide complex., Candel AM, Conejero-Lara F, Martinez JC, van Nuland NA, Bruix M, FEBS Lett. 2007 Feb 20;581(4):687-92. Epub 2007 Jan 22. PMID:17275816

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