2rf2

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[[Image:2rf2.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2rf2| PDB=2rf2 | SCENE= }}
{{STRUCTURE_2rf2| PDB=2rf2 | SCENE= }}
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'''HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)'''
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===HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)===
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==Overview==
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This Letter describes the design, synthesis, and biological evaluation of novel 3-indole sulfonamides as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) with balanced profiles against common HIV RT mutants K103N and Y181C.
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The line below this paragraph, {{ABSTRACT_PUBMED_18083561}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18083561 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18083561}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:46:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:55:21 2008''

Revision as of 02:55, 29 July 2008

Image:2rf2.png

Template:STRUCTURE 2rf2

HIV reverse transcriptase in complex with inhibitor 7e (NNRTI)

Template:ABSTRACT PUBMED 18083561

About this Structure

2RF2 is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)., Zhao Z, Wolkenberg SE, Lu M, Munshi V, Moyer G, Feng M, Carella AV, Ecto LT, Gabryelski LJ, Lai MT, Prasad SG, Yan Y, McGaughey GB, Miller MD, Lindsley CW, Hartman GD, Vacca JP, Williams TM, Bioorg Med Chem Lett. 2008 Jan 15;18(2):554-9. Epub 2007 Nov 28. PMID:18083561

Page seeded by OCA on Tue Jul 29 05:55:21 2008

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