2byq

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{{STRUCTURE_2byq| PDB=2byq | SCENE= }}
{{STRUCTURE_2byq| PDB=2byq | SCENE= }}
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'''CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH EPIBATIDINE'''
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===CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH EPIBATIDINE===
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==Overview==
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The crystal structure of the snake long alpha-neurotoxin, alpha-cobratoxin, bound to the pentameric acetylcholine-binding protein (AChBP) from Lymnaea stagnalis, was solved from good quality density maps despite a 4.2 A overall resolution. The structure unambiguously reveals the positions and orientations of all five three-fingered toxin molecules inserted at the AChBP subunit interfaces and the conformational changes associated with toxin binding. AChBP loops C and F that border the ligand-binding pocket move markedly from their original positions to wrap around the tips of the toxin first and second fingers and part of its C-terminus, while rearrangements also occur in the toxin fingers. At the interface of the complex, major interactions involve aromatic and aliphatic side chains within the AChBP binding pocket and, at the buried tip of the toxin second finger, conserved Phe and Arg residues that partially mimic a bound agonist molecule. Hence this structure, in revealing a distinctive and unpredicted conformation of the toxin-bound AChBP molecule, provides a lead template resembling a resting state conformation of the nicotinic receptor and for understanding selectivity of curaremimetic alpha-neurotoxins for the various receptor species.
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(as it appears on PubMed at http://www.pubmed.gov), where 15791209 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15791209}}
==About this Structure==
==About this Structure==
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[[Category: Nicotinic acetylcholine]]
[[Category: Nicotinic acetylcholine]]
[[Category: Receptor]]
[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:59:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:03:42 2008''

Revision as of 03:03, 29 July 2008

Image:2byq.png

Template:STRUCTURE 2byq

CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH EPIBATIDINE

Template:ABSTRACT PUBMED 15791209

About this Structure

2BYQ is a Single protein structure of sequence from Aplysia californica. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors., Bourne Y, Talley TT, Hansen SB, Taylor P, Marchot P, EMBO J. 2005 Apr 20;24(8):1512-22. Epub 2005 Mar 24. PMID:15791209

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