1pax
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(New page: 200px<br /><applet load="1pax" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pax, resolution 2.4Å" /> '''THE CATALYTIC FRAGMEN...)
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Revision as of 21:31, 20 November 2007
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THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH 3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE
Overview
The crystal structures of the catalytic fragment of chicken, poly(ADP-ribose) polymerase [NAD+ ADP-ribosyltransferase;, NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor, ADP-D-ribosyltransferase, EC 2.4.2.30] with and without a, nicotinamide-analogue inhibitor have been elucidated. Because this enzyme, is involved in the regulation of DNA repair, its inhibitors are of, interest for cancer therapy. The inhibitor shows the nicotinamide site and, also suggests the adenosine site. The enzyme is structurally related to, bacterial ADP-ribosylating toxins but contains an additional alpha-helical, domain that is suggested to relay the activation signal issued on binding, to damaged DNA.
About this Structure
1PAX is a Single protein structure of sequence from Gallus gallus with DHQ as ligand. Active as NAD(+) ADP-ribosyltransferase, with EC number 2.4.2.30 Full crystallographic information is available from OCA.
Reference
Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken., Ruf A, Mennissier de Murcia J, de Murcia G, Schulz GE, Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7481-5. PMID:8755499
Page seeded by OCA on Tue Nov 20 23:38:50 2007
