2nvw

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{{STRUCTURE_2nvw| PDB=2nvw | SCENE= }}
{{STRUCTURE_2nvw| PDB=2nvw | SCENE= }}
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'''Crystal sctucture of transcriptional regulator Gal80p from kluyveromymes lactis'''
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===Crystal sctucture of transcriptional regulator Gal80p from kluyveromymes lactis===
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==Overview==
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In yeast, the GAL genes encode the enzymes required for normal galactose metabolism. Regulation of these genes in response to the organism being challenged with galactose has served as a paradigm for eukaryotic transcriptional control over the last 50 years. Three proteins, the activator Gal4p, the repressor Gal80p, and the ligand sensor Gal3p, control the switch between inert and active gene expression. Gal80p, the focus of this investigation, plays a pivotal role both in terms of repressing the activity of Gal4p and allowing the GAL switch to respond to galactose. Here we present the three-dimensional structure of Gal80p from Kluyveromyces lactis and show that it is structurally homologous to glucose-fructose oxidoreductase, an enzyme in the sorbitol-gluconate pathway. Our results clearly define the overall tertiary and quaternary structure of Gal80p and suggest that Gal4p and Gal3p bind to Gal80p at distinct but overlapping sites. In addition to providing a molecular basis for previous biochemical and genetic studies, our structure demonstrates that much of the enzymatic scaffold of the oxidoreductase has been maintained in Gal80p, but it is utilized in a very different manner to facilitate transcriptional regulation.
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{{ABSTRACT_PUBMED_17121853}}
==About this Structure==
==About this Structure==
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[[Category: Repressor]]
[[Category: Repressor]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:58:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:06:13 2008''

Revision as of 03:06, 29 July 2008

Image:2nvw.png

Template:STRUCTURE 2nvw

Crystal sctucture of transcriptional regulator Gal80p from kluyveromymes lactis

Template:ABSTRACT PUBMED 17121853

About this Structure

2NVW is a Single protein structure of sequence from Kluyveromyces lactis. Full crystallographic information is available from OCA.

Reference

Understanding a transcriptional paradigm at the molecular level. The structure of yeast Gal80p., Thoden JB, Sellick CA, Reece RJ, Holden HM, J Biol Chem. 2007 Jan 19;282(3):1534-8. Epub 2006 Nov 22. PMID:17121853

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