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2c1y

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[[Image:2c1y.gif|left|200px]]
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{{Seed}}
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[[Image:2c1y.png|left|200px]]
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{{STRUCTURE_2c1y| PDB=2c1y | SCENE= }}
{{STRUCTURE_2c1y| PDB=2c1y | SCENE= }}
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'''STRUCTURE OF PDI-RELATED CHAPERONE, WIND MUTANT-Y55K'''
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===STRUCTURE OF PDI-RELATED CHAPERONE, WIND MUTANT-Y55K===
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==Overview==
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The structures of the PDI-related protein Wind (with a C-terminal His(6) tag) and the mutants Y53S, Y53F and Y55K have been determined and compared with the wild-type structure with the His(6) tag at the N-terminus. All five structures show the same mode of dimerization, showing that this was not an artefact introduced by the nearby N-terminal His(6) tag and suggesting that this dimer may also be the biologically active form. Although the mutants Y53S and Y55K completely abrogate transport of the protein Pipe (which appears to be the primary function of Wind in the cell), only subtle differences can be seen in the putative Pipe-binding region. The Pipe binding in the active forms appears to involve hydrophobic interactions between aromatic systems, whereas the inactive mutants may be able to bind more strongly with the help of hydrogen bonds, which could disturb the delicate equilibrium required for effective Pipe transport.
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The line below this paragraph, {{ABSTRACT_PUBMED_16699185}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16699185 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16699185}}
==About this Structure==
==About this Structure==
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[[Category: Wind mutant]]
[[Category: Wind mutant]]
[[Category: Windbeutel]]
[[Category: Windbeutel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:07:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:07:17 2008''

Revision as of 03:07, 29 July 2008

Image:2c1y.png

Template:STRUCTURE 2c1y

STRUCTURE OF PDI-RELATED CHAPERONE, WIND MUTANT-Y55K

Template:ABSTRACT PUBMED 16699185

About this Structure

2C1Y is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural elucidation of the PDI-related chaperone Wind with the help of mutants., Sevvana M, Biadene M, Ma Q, Guo C, Soling HD, Sheldrick GM, Ferrari DM, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):589-94. Epub 2006, May 12. PMID:16699185

Page seeded by OCA on Tue Jul 29 06:07:17 2008

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