1qfc

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[[Image:1qfc.jpg|left|200px]]
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{{Seed}}
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[[Image:1qfc.png|left|200px]]
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{{STRUCTURE_1qfc| PDB=1qfc | SCENE= }}
{{STRUCTURE_1qfc| PDB=1qfc | SCENE= }}
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'''STRUCTURE OF RAT PURPLE ACID PHOSPHATASE'''
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===STRUCTURE OF RAT PURPLE ACID PHOSPHATASE===
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==Overview==
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Tartrate-resistant acid phosphatase (TRAP) is a mammalian di-iron- containing enzyme that belongs to the family of purple acid phosphatases (PAP). It is highly expressed in a limited number of tissues, predominantly in bone-resorbing osteoclasts and in macrophages of spleen. We have determined the crystal structure of rat TRAP in complex with a phosphate ion to 2.7 A resolution. The fold resembles that of the catalytic domain of kidney bean purple acid phosphatase (KBPAP), although the sequence similarity is limited to the active site residues. A surface loop near the active site is absent due to proteolysis, leaving the active-site easily accessible from the surrounding solvent. This, we believe, gives a structural explanation for the observed proteolytic activation of TRAP. The current structure was determined at a relatively high pH and without any external reducing agents. It is likely that it represents an oxidized and therefore catalytically inactive form of the enzyme.
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The line below this paragraph, {{ABSTRACT_PUBMED_10388567}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10388567 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10388567}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Metal phosphatase]]
[[Category: Metal phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:11:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:10:09 2008''

Revision as of 03:10, 29 July 2008

Image:1qfc.png

Template:STRUCTURE 1qfc

STRUCTURE OF RAT PURPLE ACID PHOSPHATASE

Template:ABSTRACT PUBMED 10388567

About this Structure

1QFC is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a mammalian purple acid phosphatase., Uppenberg J, Lindqvist F, Svensson C, Ek-Rylander B, Andersson G, J Mol Biol. 1999 Jul 2;290(1):201-11. PMID:10388567

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