1t5r

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{{STRUCTURE_1t5r| PDB=1t5r | SCENE= }}
{{STRUCTURE_1t5r| PDB=1t5r | SCENE= }}
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'''STRUCTURE OF THE PANTON-VALENTINE LEUCOCIDIN S COMPONENT FROM STAPHYLOCOCCUS AUREUS'''
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===STRUCTURE OF THE PANTON-VALENTINE LEUCOCIDIN S COMPONENT FROM STAPHYLOCOCCUS AUREUS===
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==Overview==
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Staphylococcal leucocidins and gamma-hemolysins (leucotoxins) are bi-component toxins that form lytic transmembrane pores. Their cytotoxic activities require the synergistic association of a class S component and a class F component, produced as water-soluble monomers that form hetero-oligomeric membrane-associated complexes. Strains that produce the Panton-Valentine leucocidin are clinically associated with cutaneous lesions and community-acquired pneumonia. In a previous study, we determined the crystal structure of the F monomer from the Panton-Valentine leucocidin. To derive information on the second component of the leucotoxins, the x-ray structure of the S protein from the Panton-Valentine leucocidin was solved to 2.0 angstrom resolution using a tetragonal crystal form that contains eight molecules in the asymmetric unit. The structure demonstrates the different conformation of the domain involved in membrane contacts and illustrates sequence and tertiary structure variabilities of the pore-forming leucotoxins. Mutagenesis studies at a key surface residue (Thr-28) further support the important role played by these microheterogeneities for the assembly of the bipartite leucotoxins.
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(as it appears on PubMed at http://www.pubmed.gov), where 15262988 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15262988}}
==About this Structure==
==About this Structure==
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[[Category: S component leucocidin]]
[[Category: S component leucocidin]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:33:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:12:51 2008''

Revision as of 03:12, 29 July 2008

Image:1t5r.png

Template:STRUCTURE 1t5r

STRUCTURE OF THE PANTON-VALENTINE LEUCOCIDIN S COMPONENT FROM STAPHYLOCOCCUS AUREUS

Template:ABSTRACT PUBMED 15262988

About this Structure

1T5R is a Single protein structure of sequence from Staphylococcus phage pvl. Full crystallographic information is available from OCA.

Reference

Crystal structure of leucotoxin S component: new insight into the Staphylococcal beta-barrel pore-forming toxins., Guillet V, Roblin P, Werner S, Coraiola M, Menestrina G, Monteil H, Prevost G, Mourey L, J Biol Chem. 2004 Sep 24;279(39):41028-37. Epub 2004 Jul 18. PMID:15262988

Page seeded by OCA on Tue Jul 29 06:12:51 2008

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