1nm0

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{{STRUCTURE_1nm0| PDB=1nm0 | SCENE= }}
{{STRUCTURE_1nm0| PDB=1nm0 | SCENE= }}
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'''Proteus mirabilis catalase in complex with formiate'''
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===Proteus mirabilis catalase in complex with formiate===
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==Overview==
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The structure of Proteus mirabilis catalase in complex with an inhibitor, formic acid, has been solved at 2.3 A resolution. Formic acid is a key ligand of catalase because of its ability to react with the ferric enzyme, giving a high-spin iron complex. Alternatively, it can react with two transient oxidized intermediates of the enzymatic mechanism, compounds I and II. In this work, the structures of native P. mirabilis catalase (PMC) and compound I have also been determined at high resolution (2.0 and 2.5 A, respectively) from frozen crystals. Comparisons between these three PMC structures show that a water molecule present at a distance of 3.5 A from the haem iron in the resting state is absent in the formic acid complex, but reappears in compound I. In addition, movements of solvent molecules are observed during formation of compound I in a cavity located away from the active site, in which a glycerol molecule is replaced by a sulfate. These results give structural insights into the movement of solvent molecules, which may be important in the enzymatic reaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 14646074 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14646074}}
==About this Structure==
==About this Structure==
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[[Category: Pernoud, A.]]
[[Category: Pernoud, A.]]
[[Category: Alpha+beta]]
[[Category: Alpha+beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:41:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:13:11 2008''

Revision as of 03:13, 29 July 2008

Image:1nm0.png

Template:STRUCTURE 1nm0

Proteus mirabilis catalase in complex with formiate

Template:ABSTRACT PUBMED 14646074

About this Structure

1NM0 is a Single protein structure of sequence from Proteus mirabilis. Full crystallographic information is available from OCA.

Reference

Structural studies of Proteus mirabilis catalase in its ground state, oxidized state and in complex with formic acid., Andreoletti P, Pernoud A, Sainz G, Gouet P, Jouve HM, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2163-8. Epub 2003, Nov 27. PMID:14646074

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