2dyp

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[[Image:2dyp.gif|left|200px]]
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{{STRUCTURE_2dyp| PDB=2dyp | SCENE= }}
{{STRUCTURE_2dyp| PDB=2dyp | SCENE= }}
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'''Crystal Structure of LILRB2(LIR2/ILT4/CD85d) complexed with HLA-G'''
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===Crystal Structure of LILRB2(LIR2/ILT4/CD85d) complexed with HLA-G===
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==Overview==
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HLA-G is a nonclassical MHC class I (MHCI) molecule that can suppress a wide range of immune responses in the maternal-fetal interface. The human inhibitory immune receptors leukocyte Ig-like receptor (LILR) B1 [also called LIR1, Ig-like transcript 2 (ILT2), or CD85j] and LILRB2 (LIR2/ILT4/CD85d) preferentially recognize HLA-G. HLA-G inherently exhibits various forms, including beta(2)-microglobulin (beta(2)m)-free and disulfide-linked dimer forms. Notably, LILRB1 cannot recognize the beta(2)m-free form of HLA-G or HLA-B27, but LILRB2 can recognize the beta(2)m-free form of HLA-B27. To date, the structural basis for HLA-G/LILR recognition remains to be examined. Here, we report the 2.5-A resolution crystal structure of the LILRB2/HLA-G complex. LILRB2 exhibits an overlapping but distinct MHCI recognition mode compared with LILRB1 and dominantly recognizes the hydrophobic site of the HLA-G alpha3 domain. NMR binding studies also confirmed these LILR recognition differences on both conformed (heavy chain/peptide/beta(2)m) and free forms of beta(2)m. Binding studies using beta(2)m-free MHCIs revealed differential beta(2)m-dependent LILR-binding specificities. These results suggest that subtle structural differences between LILRB family members cause the distinct binding specificities to various forms of HLA-G and other MHCIs, which may in turn regulate immune suppression.
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(as it appears on PubMed at http://www.pubmed.gov), where 17056715 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17056715}}
==About this Structure==
==About this Structure==
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[[Category: Shiroishi, M.]]
[[Category: Shiroishi, M.]]
[[Category: Immunoglobulin-like]]
[[Category: Immunoglobulin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:37:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:17:31 2008''

Revision as of 03:17, 29 July 2008

Image:2dyp.png

Template:STRUCTURE 2dyp

Crystal Structure of LILRB2(LIR2/ILT4/CD85d) complexed with HLA-G

Template:ABSTRACT PUBMED 17056715

About this Structure

2DYP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)., Shiroishi M, Kuroki K, Rasubala L, Tsumoto K, Kumagai I, Kurimoto E, Kato K, Kohda D, Maenaka K, Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16412-7. Epub 2006 Oct 20. PMID:17056715

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