2azk

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[[Image:2azk.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2azk| PDB=2azk | SCENE= }}
{{STRUCTURE_2azk| PDB=2azk | SCENE= }}
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'''Crystal structure for the mutant W136E of Sulfolobus solfataricus hexaprenyl pyrophosphate synthase'''
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===Crystal structure for the mutant W136E of Sulfolobus solfataricus hexaprenyl pyrophosphate synthase===
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==Overview==
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Hexaprenyl pyrophosphate synthase (HexPPs) from Sulfolobus solfataricus catalyzes the synthesis of trans-C(30)-hexaprenyl pyrophosphate (HexPP) by reacting two isopentenyl pyrophosphate molecules with one geranylgeranyl pyrophosphate. The crystal structure of the homodimeric C(30)-HexPPs resembles those of other trans-prenyltransferases, including farnesyl pyrophosphate synthase (FPPs) and octaprenyl pyrophosphate synthase (OPPs). In both subunits, 10 core helices are arranged about a central active site cavity. Leu164 in the middle of the cavity controls the product chain length. Two protein conformers are observed in the S. solfataricus HexPPs structure, and the major difference between them occurs in the flexible region of residues 84 to 100. Several helices (alphaI, alphaJ, alphaK, and part of alphaH) and the associated loops have high-temperature factors in one monomer, which may be related to the domain motion that controls the entrance to the active site. Different side chain conformations of Trp136 in two HexPPs subunits result in weaker hydrophobic interactions at the dimer interface, in contrast to the symmetric pi-pi stacking interactions of aromatic side chains found in FPPs and OPPs. Finally, the three-conformer switched model may explain the catalytic process for HexPPs.
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(as it appears on PubMed at http://www.pubmed.gov), where 16291686 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16291686}}
==About this Structure==
==About this Structure==
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[[Category: Isoprenyl pyrophosphate synthase]]
[[Category: Isoprenyl pyrophosphate synthase]]
[[Category: Trans-prenyltransferase]]
[[Category: Trans-prenyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:39:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:18:01 2008''

Revision as of 03:18, 29 July 2008

Image:2azk.png

Template:STRUCTURE 2azk

Crystal structure for the mutant W136E of Sulfolobus solfataricus hexaprenyl pyrophosphate synthase

Template:ABSTRACT PUBMED 16291686

About this Structure

2AZK is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures., Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH, J Bacteriol. 2005 Dec;187(23):8137-48. PMID:16291686

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