1op9

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{{STRUCTURE_1op9| PDB=1op9 | SCENE= }}
{{STRUCTURE_1op9| PDB=1op9 | SCENE= }}
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'''Complex of human lysozyme with camelid VHH HL6 antibody fragment'''
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===Complex of human lysozyme with camelid VHH HL6 antibody fragment===
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==Overview==
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Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues, often with serious pathological consequences. Non-neuropathic systemic amyloidosis is associated with single point mutations in the gene coding for human lysozyme. Here we report that a single-domain fragment of a camelid antibody raised against wild-type human lysozyme inhibits the in vitro aggregation of its amyloidogenic variant, D67H. Our structural studies reveal that the epitope includes neither the site of mutation nor most residues in the region of the protein structure that is destabilized by the mutation. Instead, the binding of the antibody fragment achieves its effect by restoring the structural cooperativity characteristic of the wild-type protein. This appears to occur at least in part through the transmission of long-range conformational effects to the interface between the two structural domains of the protein. Thus, reducing the ability of an amyloidogenic protein to form partly unfolded species can be an effective method of preventing its aggregation, suggesting approaches to the rational design of therapeutic agents directed against protein deposition diseases.
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The line below this paragraph, {{ABSTRACT_PUBMED_12917687}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12917687 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12917687}}
==About this Structure==
==About this Structure==
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[[Category: Antigen-antibody complex]]
[[Category: Antigen-antibody complex]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:07:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:23:11 2008''

Revision as of 03:23, 29 July 2008

Image:1op9.png

Template:STRUCTURE 1op9

Complex of human lysozyme with camelid VHH HL6 antibody fragment

Template:ABSTRACT PUBMED 12917687

About this Structure

1OP9 is a Single protein structure of sequence from Camelus dromedarius and Homo sapiens. Full crystallographic information is available from OCA.

Reference

A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme., Dumoulin M, Last AM, Desmyter A, Decanniere K, Canet D, Larsson G, Spencer A, Archer DB, Sasse J, Muyldermans S, Wyns L, Redfield C, Matagne A, Robinson CV, Dobson CM, Nature. 2003 Aug 14;424(6950):783-8. PMID:12917687

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