1txu

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{{STRUCTURE_1txu| PDB=1txu | SCENE= }}
{{STRUCTURE_1txu| PDB=1txu | SCENE= }}
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'''Crystal Structure of the Vps9 Domain of Rabex-5'''
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===Crystal Structure of the Vps9 Domain of Rabex-5===
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==Overview==
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The Rab5 GTPase, an essential regulator of endocytosis and endosome biogenesis, is activated by guanine-nucleotide exchange factors (GEFs) that contain a Vps9 domain. Here, we show that the catalytic core of the Rab GEF Rabex-5 has a tandem architecture consisting of a Vps9 domain stabilized by an indispensable helical bundle. A family-wide analysis of Rab specificity demonstrates high selectivity for Rab5 subfamily GTPases. Conserved exchange determinants map to a common surface of the Vps9 domain, which recognizes invariant aromatic residues in the switch regions of Rab GTPases and selects for the Rab5 subfamily by requiring a small nonacidic residue preceding a critical phenylalanine in the switch I region. These and other observations reveal unexpected similarity with the Arf exchange site in the Sec7 domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 15339665 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15339665}}
==About this Structure==
==About this Structure==
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[[Category: Rab5 guanine-nucleotide exchange factor,gef]]
[[Category: Rab5 guanine-nucleotide exchange factor,gef]]
[[Category: Vps9 domain]]
[[Category: Vps9 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:30:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:26:19 2008''

Revision as of 03:26, 29 July 2008

Image:1txu.png

Template:STRUCTURE 1txu

Crystal Structure of the Vps9 Domain of Rabex-5

Template:ABSTRACT PUBMED 15339665

About this Structure

1TXU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5., Delprato A, Merithew E, Lambright DG, Cell. 2004 Sep 3;118(5):607-17. PMID:15339665

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