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1oio

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[[Image:1oio.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1oio| PDB=1oio | SCENE= }}
{{STRUCTURE_1oio| PDB=1oio | SCENE= }}
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'''GAFD (F17C-TYPE) FIMBRIAL ADHESIN FROM ESCHERICHIA COLI'''
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===GAFD (F17C-TYPE) FIMBRIAL ADHESIN FROM ESCHERICHIA COLI===
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==Overview==
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GafD in Escherichia coli G (F17) fimbriae is associated with diarrheal disease, and the structure of the ligand-binding domain, GafD1-178, has been determined at 1.7A resolution in the presence of the receptor sugar N-acetyl-D-glucosamine. The overall fold is a beta-barrel jelly-roll fold. The ligand-binding site was identified and localized to the side of the molecule. Receptor binding is mediated by side-chain as well main-chain interactions. Ala43-Asn44, Ser116-Thr117 form the sugar acetamide specificity pocket, while Asp88 confers tight binding and Trp109 appears to position the ligand. There is a disulfide bond that rigidifies the acetamide specificity pocket. The three fimbrial lectins, GafD, FimH and PapG share similar beta-barrel folds but display different ligand-binding regions and disulfide-bond patterns. We suggest an evolutionary path for the evolution of the very diverse fimbrial lectins from a common ancestral fold.
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The line below this paragraph, {{ABSTRACT_PUBMED_12909017}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12909017 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12909017}}
==About this Structure==
==About this Structure==
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[[Category: Glcnac binding lectin]]
[[Category: Glcnac binding lectin]]
[[Category: N-acetyl-d-glucosamine binding]]
[[Category: N-acetyl-d-glucosamine binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:53:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:26:40 2008''

Revision as of 03:26, 29 July 2008

Image:1oio.png

Template:STRUCTURE 1oio

GAFD (F17C-TYPE) FIMBRIAL ADHESIN FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 12909017

About this Structure

1OIO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structural basis of receptor-binding by Escherichia coli associated with diarrhea and septicemia., Merckel MC, Tanskanen J, Edelman S, Westerlund-Wikstrom B, Korhonen TK, Goldman A, J Mol Biol. 2003 Aug 22;331(4):897-905. PMID:12909017

Page seeded by OCA on Tue Jul 29 06:26:40 2008

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