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1rg0

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[[Image:1rg0.gif|left|200px]]
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{{STRUCTURE_1rg0| PDB=1rg0 | SCENE= }}
{{STRUCTURE_1rg0| PDB=1rg0 | SCENE= }}
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'''Monoclinic crystal form of the truncated K122-4 pilin from Pseudomonas aeruginosa'''
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===Monoclinic crystal form of the truncated K122-4 pilin from Pseudomonas aeruginosa===
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==Overview==
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Adherence of pathogens to host cells is critical for the initiation of infection and is thus an attractive target for anti-infective therapeutics and vaccines. In the opportunistic human pathogen Pseudomonas aeruginosa, host-cell adherence is achieved predominantly by type IV pili. Analysis of several clinical strains of P. aeruginosa reveals poor sequence conservation between pilin genes, including the residues in the receptor-binding site. Interestingly, the receptor-binding sites appear to retain a conserved surface epitope because all Pseudomonas type IV pili recognize the same receptor on the host cell and cross-reactive antibodies specific for the receptor-binding site exist. Here, we present the crystallographic analysis of two crystal forms of truncated pilin from P. aeruginosa strain K122-4 (DeltaK122-4) at 1.54 and 1.8 A resolution, respectively. The DeltaK122-4 structure is compared to other crystallographically determined type IV pilin structures and an NMR structure of DeltaK122-4 pilin. A comparison with the structure of the highly divergent P. aeruginosa strain K (DeltaPAK) pilin indicates that the receptor-binding loop in both pilins forms a shallow depression with a surface that is formed by main-chain atoms. Conservation of this putative binding site is independent of the sequence as long as the main-chain conformation is conserved and could therefore explain the shared receptor specificity and antibody cross reactivity of highly divergent Pseudomonas type IV pilins.
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(as it appears on PubMed at http://www.pubmed.gov), where 15350129 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15350129}}
==About this Structure==
==About this Structure==
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[[Category: Pseudomona]]
[[Category: Pseudomona]]
[[Category: Type iv pilin]]
[[Category: Type iv pilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:27:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:28:49 2008''

Revision as of 03:28, 29 July 2008

Image:1rg0.png

Template:STRUCTURE 1rg0

Monoclinic crystal form of the truncated K122-4 pilin from Pseudomonas aeruginosa

Template:ABSTRACT PUBMED 15350129

About this Structure

1RG0 is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of the Pseudomonas aeruginosa strain K122-4 monomeric pilin reveals a conserved receptor-binding architecture., Audette GF, Irvin RT, Hazes B, Biochemistry. 2004 Sep 14;43(36):11427-35. PMID:15350129

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