1xtn

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[[Image:1xtn.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1xtn| PDB=1xtn | SCENE= }}
{{STRUCTURE_1xtn| PDB=1xtn | SCENE= }}
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'''crystal structure of CISK-PX domain with sulfates'''
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===crystal structure of CISK-PX domain with sulfates===
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==Overview==
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The cytokine-independent survival kinase (CISK) in the serum and glucocorticoid-regulated kinase family plays an important role in mediating cell growth and survival. N-terminal to its catalytic kinase domain, CISK contains a phox homology (PX) domain, a phosphoinositide-binding motif that directs the membrane localization of CISK and regulates CISK activity. We have determined the crystal structures of the mouse CISK-PX domain to unravel the structural basis of membrane targeting of CISK. In addition to the specific interactions conferred by the phosphoinositide-binding pocket, the structure suggests that a hydrophobic loop region and a hydrophilic beta-turn contribute to the interactions with the membrane. Furthermore, biochemical studies reveal that CISK-PX dimerizes in the presence of the linker between the PX domain and kinase domain, suggesting a multivalent mechanism in membrane localization of CISK.
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The line below this paragraph, {{ABSTRACT_PUBMED_15126499}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15126499 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15126499}}
==About this Structure==
==About this Structure==
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[[Category: Crystal structure]]
[[Category: Crystal structure]]
[[Category: Px domain]]
[[Category: Px domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:29:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:29:18 2008''

Revision as of 03:29, 29 July 2008

Image:1xtn.png

Template:STRUCTURE 1xtn

crystal structure of CISK-PX domain with sulfates

Template:ABSTRACT PUBMED 15126499

About this Structure

1XTN is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX)., Xing Y, Liu D, Zhang R, Joachimiak A, Songyang Z, Xu W, J Biol Chem. 2004 Jul 16;279(29):30662-9. Epub 2004 May 4. PMID:15126499

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