1n88

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{{STRUCTURE_1n88| PDB=1n88 | SCENE= }}
{{STRUCTURE_1n88| PDB=1n88 | SCENE= }}
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'''NMR structure of the ribosomal protein L23 from Thermus thermophilus.'''
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===NMR structure of the ribosomal protein L23 from Thermus thermophilus.===
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==Overview==
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The ribosomal protein L23 is a component of the large ribosomal subunit in which it is located close to the peptide exit tunnel. In this position L23 plays a central role both for protein secretion and folding. We have determined the solution structure of L23 from Thermus thermophilus. Uncomplexed L23 consists of a well-ordered part, with four anti-parallel beta-strands and three alpha-helices connected as beta-alpha-beta-alpha-beta-beta-alpha, and a large and flexible loop inserted between the third and fourth beta-strand. The observed topology is distantly related to previously known structures, primarily within the area of RNA biochemistry. A comparison with RNA-complexed crystal structures of L23 from T. thermophilus, Deinococcus radiodurans and Haloarcula marismourtui, shows that the conformation of the well-ordered part is very similar in the uncomplexed and complexed states. However, the flexible loop found in the uncomplexed solution structure forms a rigid extended structure in the complexed crystal structures as it interacts with rRNA and becomes part of the exit tunnel wall. Structural characteristics of importance for the interaction with rRNA and with the ribosomal protein L29, as well as the functional role of L23, are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 12766408 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12766408}}
==About this Structure==
==About this Structure==
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1N88 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N88 OCA].
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1N88 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N88 OCA].
==Reference==
==Reference==
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[[Category: Ribosome]]
[[Category: Ribosome]]
[[Category: Translation]]
[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:13:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:29:35 2008''

Revision as of 03:29, 29 July 2008

Image:1n88.png

Template:STRUCTURE 1n88

NMR structure of the ribosomal protein L23 from Thermus thermophilus.

Template:ABSTRACT PUBMED 12766408

About this Structure

1N88 is a Single protein structure of sequence from Thermus thermophilus. Full experimental information is available from OCA.

Reference

NMR structure of the ribosomal protein L23 from Thermus thermophilus., Ohman A, Rak A, Dontsova M, Garber MB, Hard T, J Biomol NMR. 2003 Jun;26(2):131-7. PMID:12766408

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