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1w0m
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(New page: 200px<br /> <applet load="1w0m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w0m, resolution 2.5Å" /> '''TRIOSEPHOSPHATE ISOM...)
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Revision as of 18:39, 29 October 2007
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TRIOSEPHOSPHATE ISOMERASE FROM THERMOPROTEUS TENAX
Overview
Triosephophate isomerase (TIM) is a dimeric enzyme in eucarya, bacteria, and mesophilic archaea. In hyperthermophilic archaea, however, TIM exists, as a tetramer composed of monomers that are about 10% shorter than other, eucaryal and bacterial TIM monomers. We report here the crystal structure, of TIM from Thermoproteus tenax, a hyperthermophilic archaeon that has an, optimum growth temperature of 86 degrees C. The structure was determined, from both a hexagonal and an orthorhombic crystal form to resolutions of, 2.5A and 2.3A, and refined to R-factors of 19.7% and 21.5%, respectively., In both crystal forms, T.tenax TIM exists as a tetramer of the familiar, (betaalpha)(8)-barrel. In solution, however, and unlike other, hyperthermophilic TIMs, the T.tenax enzyme exhibits an equilibrium ... [(full description)]
About this Structure
1W0M is a [Single protein] structure of sequence from [Thermoproteus tenax] with PO4 as [ligand]. Active as [[1]], with EC number [5.3.1.1]. Full crystallographic information is available from [OCA].
Reference
Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature., Walden H, Taylor GL, Lorentzen E, Pohl E, Lilie H, Schramm A, Knura T, Stubbe K, Tjaden B, Hensel R, J Mol Biol. 2004 Sep 17;342(3):861-75. PMID:15342242
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