2fci

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[[Image:2fci.gif|left|200px]]
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{{STRUCTURE_2fci| PDB=2fci | SCENE= }}
{{STRUCTURE_2fci| PDB=2fci | SCENE= }}
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'''Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase'''
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===Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase===
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==Overview==
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The protein-tyrosine kinase Syk couples immune recognition receptors to multiple signal transduction pathways, including the mobilization of calcium and the activation of NFAT. The ability of Syk to regulate signaling is influenced by its phosphorylation on tyrosine residues within the linker B region. The phosphorylation of both Y342 and Y346 is necessary for optimal signaling from the B cell receptor for antigen. The SH2 domains of multiple signaling proteins share the ability to bind this doubly phosphorylated site. The NMR structure of the C-terminal SH2 domain of PLCgamma (PLCC) bound to a doubly phosphorylated Syk peptide reveals a novel mode of phosphotyrosine recognition. PLCC undergoes extensive conformational changes upon binding to form a second phosphotyrosine-binding pocket in which pY346 is largely desolvated and stabilized through electrostatic interactions. The formation of the second binding pocket is distinct from other modes of phosphotyrosine recognition in SH2-protein association. The dependence of signaling on simultaneous phosphorylation of these two tyrosine residues offers a new mechanism to fine-tune the cellular response to external stimulation.
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The line below this paragraph, {{ABSTRACT_PUBMED_16410013}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16410013 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16410013}}
==About this Structure==
==About this Structure==
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2FCI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCI OCA].
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2FCI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCI OCA].
==Reference==
==Reference==
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[[Category: Sh2 domain]]
[[Category: Sh2 domain]]
[[Category: Syk kinase]]
[[Category: Syk kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:43:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:31:57 2008''

Revision as of 03:31, 29 July 2008

Image:2fci.png

Template:STRUCTURE 2fci

Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase

Template:ABSTRACT PUBMED 16410013

About this Structure

2FCI is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase., Groesch TD, Zhou F, Mattila S, Geahlen RL, Post CB, J Mol Biol. 2006 Mar 10;356(5):1222-36. Epub 2005 Dec 27. PMID:16410013

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