2q1l

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{{STRUCTURE_2q1l| PDB=2q1l | SCENE= }}
{{STRUCTURE_2q1l| PDB=2q1l | SCENE= }}
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'''Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors'''
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===Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors===
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==Overview==
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This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a pre-clinical animal models.
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(as it appears on PubMed at http://www.pubmed.gov), where 17574412 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17574412}}
==Disease==
==Disease==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Statin]]
[[Category: Statin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:10:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:34:46 2008''

Revision as of 03:34, 29 July 2008

Image:2q1l.png

Template:STRUCTURE 2q1l

Contents

Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors

Template:ABSTRACT PUBMED 17574412

Disease

Known disease associated with this structure: Statins, attenuated cholesterol lowering by OMIM:[142910]

About this Structure

2Q1L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors., Pfefferkorn JA, Song Y, Sun KL, Miller SR, Trivedi BK, Choi C, Sorenson RJ, Bratton LD, Unangst PC, Larsen SD, Poel TJ, Cheng XM, Lee C, Erasga N, Auerbach B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Olsen K, Mertz T, Sekerke C, Pavlovsky A, Harris MS, Bainbridge G, Caspers N, Chen H, Eberstadt M, Bioorg Med Chem Lett. 2007 Aug 15;17(16):4538-44. Epub 2007 Jun 6. PMID:17574412

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