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3c60

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{{STRUCTURE_3c60| PDB=3c60 | SCENE= }}
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'''Crystal structure of mouse MHC class II I-Ab/3K peptide complexed with mouse TCR YAe62'''
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===Crystal structure of mouse MHC class II I-Ab/3K peptide complexed with mouse TCR YAe62===
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==Overview==
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To test whether highly crossreactive alphabeta T cell receptors (TCRs) produced during limited negative selection best illustrate evolutionarily conserved interactions between TCR and major histocompatibility complex (MHC) molecules, we solved the structures of three TCRs bound to the same MHC II peptide (IAb-3K). The TCRs had similar affinities for IAb-3K but varied from noncrossreactive to extremely crossreactive with other peptides and MHCs. Crossreactivity correlated with a shrinking, increasingly hydrophobic TCR-ligand interface, involving fewer TCR amino acids. A few CDR1 and CDR2 amino acids dominated the most crossreactive TCR interface with MHC, including Vbeta8 48Y and 54E and Valpha4 29Y, arranged to impose the familiar diagonal orientation of TCR on MHC. These interactions contribute to MHC binding by other TCRs using related V regions, but not usually so dominantly. These data show that crossreactive TCRs can spotlight the evolutionarily conserved features of TCR-MHC interactions and that these interactions impose the diagonal docking of TCRs on MHC.
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==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:34:48 2008''

Revision as of 03:34, 29 July 2008

Image:3c60.png

Template:STRUCTURE 3c60

Crystal structure of mouse MHC class II I-Ab/3K peptide complexed with mouse TCR YAe62

Template:ABSTRACT PUBMED 18308592

About this Structure

3C60 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules., Dai S, Huseby ES, Rubtsova K, Scott-Browne J, Crawford F, Macdonald WA, Marrack P, Kappler JW, Immunity. 2008 Mar;28(3):324-34. Epub 2008 Feb 28. PMID:18308592

Page seeded by OCA on Tue Jul 29 06:34:48 2008

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