1zhn

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{{STRUCTURE_1zhn| PDB=1zhn | SCENE= }}
{{STRUCTURE_1zhn| PDB=1zhn | SCENE= }}
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'''Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine'''
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===Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine===
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==Overview==
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NKT cells are immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we present the crystal structure to 2.8 A of mouse CD1d bound to phosphatidylcholine. The interactions between the ligand acyl chains and the CD1d molecule define the structural and chemical requirements for the binding of lipid Ags to CD1d. The orientation of the polar headgroup toward the C terminus of the alpha1 helix provides a rationale for the structural basis for the observed Valpha chain bias in invariant NKT cells. The contribution of the ligand to the protein surface suggests a likely mode of recognition of lipid Ags by the NKT cell TCR.
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(as it appears on PubMed at http://www.pubmed.gov), where 16002697 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16002697}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:38:23 2008''

Revision as of 03:38, 29 July 2008

Image:1zhn.png

Template:STRUCTURE 1zhn

Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine

Template:ABSTRACT PUBMED 16002697

About this Structure

1ZHN is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation., Giabbai B, Sidobre S, Crispin MD, Sanchez-Ruiz Y, Bachi A, Kronenberg M, Wilson IA, Degano M, J Immunol. 2005 Jul 15;175(2):977-84. PMID:16002697

Page seeded by OCA on Tue Jul 29 06:38:23 2008

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