1sae

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[[Image:1sae.gif|left|200px]]
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{{STRUCTURE_1sae| PDB=1sae | SCENE= }}
{{STRUCTURE_1sae| PDB=1sae | SCENE= }}
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'''HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)'''
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===HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)===
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==Overview==
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The NMR solution structure of the oligomerization domain of the tumour suppressor p53 (residues 319-360) has been refined. The structure comprises a dimer of dimers, oriented in an approximately orthogonal manner. The present structure determination is based on 4,472 experimental NMR restraints which represents a three and half fold increase over our previous work in the number of NOE restraints at the tetramerization interface. A comparison with the recently solved 1.7 A resolution X-ray structure shows that the structures are very similar and that the average angular root-mean-square difference in the interhelical angles is about 1 degree. The results of recent extensive mutagenesis data and the possible effects of mutations which have been identified in human cancers are discussed in the light of the present structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_7796267}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7796267 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7796267}}
==About this Structure==
==About this Structure==
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1SAE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAE OCA].
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1SAE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAE OCA].
==Reference==
==Reference==
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[[Category: Omichinski, J G.]]
[[Category: Omichinski, J G.]]
[[Category: Anti-oncogene]]
[[Category: Anti-oncogene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:28:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:45:52 2008''

Revision as of 03:45, 29 July 2008

Image:1sae.png

Template:STRUCTURE 1sae

HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)

Template:ABSTRACT PUBMED 7796267

About this Structure

1SAE is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Refined solution structure of the oligomerization domain of the tumour suppressor p53., Clore GM, Ernst J, Clubb R, Omichinski JG, Kennedy WM, Sakaguchi K, Appella E, Gronenborn AM, Nat Struct Biol. 1995 Apr;2(4):321-33. PMID:7796267

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