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2h4t

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{{STRUCTURE_2h4t| PDB=2h4t | SCENE= }}
{{STRUCTURE_2h4t| PDB=2h4t | SCENE= }}
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'''Crystal structure of rat carnitine palmitoyltransferase II'''
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===Crystal structure of rat carnitine palmitoyltransferase II===
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==Overview==
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Carnitine palmitoyltransferase II (CPT-II) has a crucial role in the beta-oxidation of long-chain fatty acids in mitochondria. We report here the crystal structure of rat CPT-II at 1.9A resolution. The overall structure shares strong similarity to those of short- and medium-chain carnitine acyltransferases, although detailed structural differences in the active site region have a significant impact on the substrate selectivity of CPT-II. Three aliphatic chains, possibly from a detergent that is used for the crystallization, were found in the structure. Two of them are located in the carnitine and CoA binding sites, respectively. The third aliphatic chain may mimic the long-chain acyl group in the substrate of CPT-II. The binding site for this aliphatic chain does not exist in the short- and medium-chain carnitine acyltransferases, due to conformational differences among the enzymes. A unique insert in CPT-II is positioned on the surface of the enzyme, with a highly hydrophobic surface. It is likely that this surface patch mediates the association of CPT-II with the inner membrane of the mitochondria.
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(as it appears on PubMed at http://www.pubmed.gov), where 16781677 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16781677}}
==About this Structure==
==About this Structure==
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[[Category: Tong, L.]]
[[Category: Tong, L.]]
[[Category: Carnitine acyltransferase]]
[[Category: Carnitine acyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:51:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:47:57 2008''

Revision as of 03:48, 29 July 2008

Image:2h4t.png

Template:STRUCTURE 2h4t

Crystal structure of rat carnitine palmitoyltransferase II

Template:ABSTRACT PUBMED 16781677

About this Structure

2H4T is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of rat carnitine palmitoyltransferase II (CPT-II)., Hsiao YS, Jogl G, Esser V, Tong L, Biochem Biophys Res Commun. 2006 Aug 4;346(3):974-80. Epub 2006 Jun 9. PMID:16781677

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