2ple

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[[Image:2ple.jpg|left|200px]]
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{{Seed}}
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[[Image:2ple.png|left|200px]]
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{{STRUCTURE_2ple| PDB=2ple | SCENE= }}
{{STRUCTURE_2ple| PDB=2ple | SCENE= }}
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'''NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE'''
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===NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE===
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==Overview==
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The solution structure of the C-terminal SH2 domain of phospholipase C-gamma 1 (PLC-gamma 1), in complex with a phosphopeptide corresponding to its Tyr-1021 high affinity binding site on the platelet-derived growth factor receptor, has been determined by nuclear magnetic resonance spectroscopy. The topology of the SH2-phosphopeptide complex is similar to previously reported Src and Lck SH2 complexes. However, the binding site for residues C-terminal to the phosphotyrosine (pTyr) is an extended groove that contacts peptide residues at the +1 to +6 positions relative to the pTyr. This striking difference from Src and Lck reflects the fact that the PLC-gamma 1 complex involves binding of a phosphopeptide with predominantly hydrophobic residues C-terminal to the pTyr and therefore serves as a prototype for a second class of SH2-phosphopeptide interactions.
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The line below this paragraph, {{ABSTRACT_PUBMED_8181064}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8181064 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8181064}}
==About this Structure==
==About this Structure==
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2PLE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLE OCA].
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2PLE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLE OCA].
==Reference==
==Reference==
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[[Category: Yamazaki, T.]]
[[Category: Yamazaki, T.]]
[[Category: Phosphoric diester hydrolase]]
[[Category: Phosphoric diester hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:21:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:59:51 2008''

Revision as of 03:59, 29 July 2008

Image:2ple.png

Template:STRUCTURE 2ple

NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE

Template:ABSTRACT PUBMED 8181064

About this Structure

2PLE is a Protein complex structure of sequences from Bos taurus. Full experimental information is available from OCA.

Reference

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide., Pascal SM, Singer AU, Gish G, Yamazaki T, Shoelson SE, Pawson T, Kay LE, Forman-Kay JD, Cell. 1994 May 6;77(3):461-72. PMID:8181064

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