1ox3

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{{STRUCTURE_1ox3| PDB=1ox3 | SCENE= }}
{{STRUCTURE_1ox3| PDB=1ox3 | SCENE= }}
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'''crystal structure of mini-fibritin'''
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===crystal structure of mini-fibritin===
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==Overview==
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Fibritin is a fibrous protein that forms "whiskers" attached to the neck of bacteriophage T4. Whiskers interact with the long tail fibers regulating the assembly and infectivity of the virus. The fibritin trimer includes the N-terminal domain responsible for attachment to the phage particle and for the collar formation, the central domain forming a 500 A long segmented coiled-coil structure, and the C-terminal "foldon" domain. We have designed a "mini" fibritin with most of the coiled-coil domain deleted, and solved its crystal structure. The non-helical N-terminal part represents a new protein fold that tightly interacts with the coiled-coil segment forming a single domain, as revealed by calorimetry. The analysis of the crystal structure and earlier electron microscopy data on the collar-whisker complex suggests the necessity of other proteins to participate in the collar formation. Crystal structure determination of the N-terminal domain of fibritin is the first step towards elucidating the detailed structure and assembly mechanism of the collar-whisker complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 15165860 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15165860}}
==About this Structure==
==About this Structure==
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[[Category: Coiled coil]]
[[Category: Coiled coil]]
[[Category: Foldon]]
[[Category: Foldon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:00:44 2008''

Revision as of 04:00, 29 July 2008

Image:1ox3.png

Template:STRUCTURE 1ox3

crystal structure of mini-fibritin

Template:ABSTRACT PUBMED 15165860

About this Structure

1OX3 is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Design and crystal structure of bacteriophage T4 mini-fibritin NCCF., Boudko SP, Strelkov SV, Engel J, Stetefeld J, J Mol Biol. 2004 Jun 11;339(4):927-35. PMID:15165860

Page seeded by OCA on Tue Jul 29 07:00:44 2008

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