2g1g

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{{STRUCTURE_2g1g| PDB=2g1g | SCENE= }}
{{STRUCTURE_2g1g| PDB=2g1g | SCENE= }}
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'''Solution structure of the anticodon loop of S. Pombe tRNAi including the naturally occurring N6-threonyl adenine'''
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===Solution structure of the anticodon loop of S. Pombe tRNAi including the naturally occurring N6-threonyl adenine===
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==Overview==
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Modified nucleosides play an important role in structure and function of tRNA. We have determined the solution structure of the anticodon stem-loop (ASL) of initiator tRNA of Schizosaccharomyces pombe. The incorporation of N6-threonylcarbamoyladenosine at the position 3' to the anticodon triplet (t6A37) results in the formation of a U-turn motif and enhances stacking interactions within the loop and stem regions (i.e. between A35 and t6A37) by bulging out U36. This conformation was not observed in a crystal structure of tRNAi including the same modification in its anticodon loop, nor in the solution structure of the unmodified ASL. A t6A modification also occurs in the well studied anti-stem-loop of lys-tRNA(UUU). A comparison of this stem-loop with our structure demonstrates different effects of the modification depending on the loop sequence.
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The line below this paragraph, {{ABSTRACT_PUBMED_16738127}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16738127 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16738127}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G1G OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G1G OCA].
==Reference==
==Reference==
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[[Category: Lescrinier, E.]]
[[Category: Lescrinier, E.]]
[[Category: T-rnai anticodonloop t6a]]
[[Category: T-rnai anticodonloop t6a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:35:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:00:51 2008''

Revision as of 04:00, 29 July 2008

Image:2g1g.png

Template:STRUCTURE 2g1g

Solution structure of the anticodon loop of S. Pombe tRNAi including the naturally occurring N6-threonyl adenine

Template:ABSTRACT PUBMED 16738127

About this Structure

Full experimental information is available from OCA.

Reference

The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes formation of a unique U-turn motif., Lescrinier E, Nauwelaerts K, Zanier K, Poesen K, Sattler M, Herdewijn P, Nucleic Acids Res. 2006 May 31;34(10):2878-86. Print 2006. PMID:16738127

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