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2a55

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[[Image:2a55.gif|left|200px]]
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{{STRUCTURE_2a55| PDB=2a55 | SCENE= }}
{{STRUCTURE_2a55| PDB=2a55 | SCENE= }}
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'''Solution structure of the two N-terminal CCP modules of C4b-binding protein (C4BP) alpha-chain.'''
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===Solution structure of the two N-terminal CCP modules of C4b-binding protein (C4BP) alpha-chain.===
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==Overview==
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Human C4b-binding protein (C4BP) protects host tissue, and those pathogens able to hijack this plasma glycoprotein, from complement-mediated destruction. We now show that the first two complement control protein (CCP) modules of the C4BP alpha-chain, plus the four residues connecting them, are necessary and sufficient for binding a bacterial virulence factor, the Streptococcus pyogenes M4 (Arp4) protein. Structure determination by NMR reveals two tightly coupled CCP modules in an elongated arrangement within this region of C4BP. Chemical shift perturbation studies demonstrate that the N-terminal, hypervariable region of M4 binds to a site including strand 1 of CCP module 2. This interaction is accompanied by an intermodular reorientation within C4BP. We thus provide a detailed picture of an interaction whereby a pathogen evades complement.
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(as it appears on PubMed at http://www.pubmed.gov), where 16330538 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16330538}}
==About this Structure==
==About this Structure==
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2A55 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A55 OCA].
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2A55 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A55 OCA].
==Reference==
==Reference==
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[[Category: Complement]]
[[Category: Complement]]
[[Category: Scr]]
[[Category: Scr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:37:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:04:38 2008''

Revision as of 04:04, 29 July 2008

Image:2a55.png

Template:STRUCTURE 2a55

Solution structure of the two N-terminal CCP modules of C4b-binding protein (C4BP) alpha-chain.

Template:ABSTRACT PUBMED 16330538

About this Structure

2A55 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor., Jenkins HT, Mark L, Ball G, Persson J, Lindahl G, Uhrin D, Blom AM, Barlow PN, J Biol Chem. 2006 Feb 10;281(6):3690-7. Epub 2005 Dec 5. PMID:16330538

Page seeded by OCA on Tue Jul 29 07:04:38 2008

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