2qmf

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[[Image:2qmf.jpg|left|200px]]
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{{Seed}}
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[[Image:2qmf.png|left|200px]]
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{{STRUCTURE_2qmf| PDB=2qmf | SCENE= }}
{{STRUCTURE_2qmf| PDB=2qmf | SCENE= }}
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'''Structure of BACE Bound to SCH735310'''
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===Structure of BACE Bound to SCH735310===
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==Overview==
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Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the most potent inhibitors synthesized to date.
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The line below this paragraph, {{ABSTRACT_PUBMED_18023580}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18023580 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18023580}}
==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:12:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:06:23 2008''

Revision as of 04:06, 29 July 2008

Image:2qmf.png

Template:STRUCTURE 2qmf

Structure of BACE Bound to SCH735310

Template:ABSTRACT PUBMED 18023580

About this Structure

2QMF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors., Iserloh U, Wu Y, Cumming JN, Pan J, Wang LY, Stamford AW, Kennedy ME, Kuvelkar R, Chen X, Parker EM, Strickland C, Voigt J, Bioorg Med Chem Lett. 2008 Jan 1;18(1):414-7. Epub 2007 Nov 6. PMID:18023580

Page seeded by OCA on Tue Jul 29 07:06:23 2008

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