1rjb

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{{STRUCTURE_1rjb| PDB=1rjb | SCENE= }}
{{STRUCTURE_1rjb| PDB=1rjb | SCENE= }}
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'''Crystal Structure of FLT3'''
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===Crystal Structure of FLT3===
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==Overview==
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FLT3 is a type III receptor tyrosine kinase that is thought to play a key role in hematopoiesis. Certain classes of FLT3 mutations cause constitutively activated forms of the receptor that are found in significant numbers of patients with acute myelogenous leukemia (AML). The mutations occur either in the activation loop, for example, as point mutations of Asp835 or as internal tandem duplication (ITD) sequences in the juxtamembrane (JM) domain. To further understand the nature of FLT3 autoinhibition and regulation, we have determined the crystal structure of the autoinhibited form of FLT3. This structure shows the autoinhibitory conformation of a complete JM domain in this class of receptor tyrosine kinases. The detailed inhibitory mechanism of the JM domain is revealed, which is likely utilized by other members of type III receptor tyrosine kinases.
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{{ABSTRACT_PUBMED_14759363}}
==About this Structure==
==About this Structure==
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[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Structure]]
[[Category: Structure]]
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Revision as of 04:09, 29 July 2008

Image:1rjb.png

Template:STRUCTURE 1rjb

Crystal Structure of FLT3

Template:ABSTRACT PUBMED 14759363

About this Structure

1RJB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain., Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K, Mol Cell. 2004 Jan 30;13(2):169-78. PMID:14759363

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