1t27

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{{STRUCTURE_1t27| PDB=1t27 | SCENE= }}
{{STRUCTURE_1t27| PDB=1t27 | SCENE= }}
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'''THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE'''
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===THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE===
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==Overview==
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Eukaryotic phosphatidylinositol transfer protein is a ubiquitous multifunctional protein that transports phospholipids between membrane surfaces and participates in cellular phospholipid metabolism during signal transduction and vesicular trafficking. The three-dimensional structure of the alpha-isoform of rat phosphatidylinositol transfer protein complexed with one molecule of phosphatidylcholine, one of its physiological ligands, has been determined to 2.2 A resolution by x-ray diffraction techniques. A single beta-sheet and several long alpha-helices define an enclosed internal cavity in which a single molecule of the phospholipid is accommodated with its polar head group in the center of the protein and fatty acyl chains projected toward the surface. Other structural features suggest mechanisms by which cytosolic phosphatidylinositol transfer protein interacts with membranes for lipid exchange and associates with a variety of lipid and protein kinases.
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The line below this paragraph, {{ABSTRACT_PUBMED_11104777}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11104777 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11104777}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine., Yoder MD, Thomas LM, Tremblay JM, Oliver RL, Yarbrough LR, Helmkamp GM Jr, J Biol Chem. 2001 Mar 23;276(12):9246-52. Epub 2000 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11104777 11104777]
Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine., Yoder MD, Thomas LM, Tremblay JM, Oliver RL, Yarbrough LR, Helmkamp GM Jr, J Biol Chem. 2001 Mar 23;276(12):9246-52. Epub 2000 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11104777 11104777]
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X-ray analysis of crystals of rat phosphatidylinositol-transfer protein with bound phosphatidylcholine., Oliver RL, Tremblay JM, Helmkamp GM Jr, Yarbrough LR, Breakfield NW, Yoder MD, Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):522-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10089365 10089365]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Yoder, M D.]]
[[Category: Yoder, M D.]]
[[Category: Lipid binding protein]]
[[Category: Lipid binding protein]]
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Revision as of 04:10, 29 July 2008

Image:1t27.png

Template:STRUCTURE 1t27

THE STRUCTURE OF PITP COMPLEXED TO PHOSPHATIDYLCHOLINE

Template:ABSTRACT PUBMED 11104777

About this Structure

1T27 is a Single protein structure of sequence from Rattus norvegicus. This structure supersedes the now removed PDB entry 1fvz. Full crystallographic information is available from OCA.

Reference

Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine., Yoder MD, Thomas LM, Tremblay JM, Oliver RL, Yarbrough LR, Helmkamp GM Jr, J Biol Chem. 2001 Mar 23;276(12):9246-52. Epub 2000 Dec 4. PMID:11104777

X-ray analysis of crystals of rat phosphatidylinositol-transfer protein with bound phosphatidylcholine., Oliver RL, Tremblay JM, Helmkamp GM Jr, Yarbrough LR, Breakfield NW, Yoder MD, Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):522-4. PMID:10089365

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