1pu4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pu4.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1pu4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pu4| PDB=1pu4 | SCENE= }}
{{STRUCTURE_1pu4| PDB=1pu4 | SCENE= }}
-
'''Crystal structure of human vascular adhesion protein-1'''
+
===Crystal structure of human vascular adhesion protein-1===
-
==Overview==
+
<!--
-
The expression of human vascular adhesion protein-1 (hVAP-1) is induced at sites of inflammation where extravasation of lymphocytes from blood to the peripheral tissue occurs. We have solved the X-ray structure of hVAP-1, a human copper amine oxidase (CAO), which is distinguished from other CAOs in being membrane-bound. The dimer structure reveals some intriguing features that may have fundamental roles in the adhesive and enzymatic functions of hVAP-1, especially regarding the role of hVAP-1 in inflammation, lymphocyte attachment, and signaling. Firstly, Leu469 at the substrate channel may play a key role in controlling the substrate entry; depending on its conformation, it either blocks or gives access to the active site. Secondly, sugar units are clearly observed at two of the six predicted N-glycosylation sites. Moreover, mutagenesis analysis showed that all of the predicted sites were glycosylated in the protein used for crystallization. Thirdly, the existence of a solvent-exposed RGD motif at the entrance to each active site in hVAP-1 suggests that it may have a functional role.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16046623}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16046623 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16046623}}
==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Salminen, T A.]]
[[Category: Salminen, T A.]]
[[Category: Amine oxidase]]
[[Category: Amine oxidase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:29:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:10:07 2008''

Revision as of 04:10, 29 July 2008

Image:1pu4.png

Template:STRUCTURE 1pu4

Crystal structure of human vascular adhesion protein-1

Template:ABSTRACT PUBMED 16046623

About this Structure

1PU4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications., Airenne TT, Nymalm Y, Kidron H, Smith DJ, Pihlavisto M, Salmi M, Jalkanen S, Johnson MS, Salminen TA, Protein Sci. 2005 Aug;14(8):1964-74. PMID:16046623

Page seeded by OCA on Tue Jul 29 07:10:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pu4"
Personal tools