1rd9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1rd9.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1rd9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rd9| PDB=1rd9 | SCENE= }}
{{STRUCTURE_1rd9| PDB=1rd9 | SCENE= }}
-
'''Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV2'''
+
===Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV2===
-
==Overview==
+
<!--
-
A series of bivalent ligands of varying length were synthesized to inhibit the receptor-binding process of cholera toxin. Competitive surface receptor binding assays showed that significant potency gains relative to the constituent monovalent ligands were achieved independently from the ability of the extended bivalent ligands to span binding sites within the toxin pentamer. Several models that could account for the unexpected improvement in IC(50) values are examined, taking into account crystallographic analysis of each ligand in complex with the toxin pentamer. Evidence is presented that steric blocking at the receptor binding surface may play a role. The results of our study suggest that the use of relatively short, "nonspanning" bivalent ligands, or monovalent ligands of similar topology and bulk may be an effective way of blocking the interaction of multimeric proteins with their cell surface receptors.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15380181}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15380181 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15380181}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Pentamer]]
[[Category: Pentamer]]
[[Category: Toxin]]
[[Category: Toxin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:21:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:12:17 2008''

Revision as of 04:12, 29 July 2008

Image:1rd9.png

Template:STRUCTURE 1rd9

Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV2

Template:ABSTRACT PUBMED 15380181

About this Structure

1RD9 is a Single protein structure of sequence from Vibrio cholerae. Full crystallographic information is available from OCA.

Reference

Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer., Pickens JC, Mitchell DD, Liu J, Tan X, Zhang Z, Verlinde CL, Hol WG, Fan E, Chem Biol. 2004 Sep;11(9):1205-15. PMID:15380181

Page seeded by OCA on Tue Jul 29 07:12:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rd9"
Personal tools