1ons

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{{STRUCTURE_1ons| PDB=1ons | SCENE= }}
{{STRUCTURE_1ons| PDB=1ons | SCENE= }}
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'''Crystal structure of Escherichia coli heat shock protein YedU'''
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===Crystal structure of Escherichia coli heat shock protein YedU===
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==Overview==
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The mRNA of Escherichia coli yedU gene is induced 31-fold upon heat shock. The 31-kD YedU protein, also calls Hsp31, is highly conserved in several human pathogens and has chaperone activity. We solved the crystal structure of YedU at 2.2 A resolution. YedU monomer has an alpha/beta/alpha sandwich domain and a small alpha/beta domain. YedU is a dimer in solution, and its crystal structure indicates that a significant amount of surface area is buried upon dimerization. There is an extended hydrophobic patch that crosses the dimer interface on the surface of the protein. This hydrophobic patch is likely the substrate-binding site responsible for the chaperone activity. The structure also reveals a potential protease-like catalytic triad composed of Cys184, His185, and Asp213, although no enzymatic activity could be identified. YedU coordinates a metal ion using His85, His122, and Glu90. This 2-His-1-carboxylate motif is present in carboxypeptidase A (a zinc enzyme), and a number of dioxygenases and hydroxylases that utilize iron as a cofactor, suggesting another potential function for YedU.
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(as it appears on PubMed at http://www.pubmed.gov), where 14500888 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14500888}}
==About this Structure==
==About this Structure==
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[[Category: Yedu]]
[[Category: Yedu]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:04:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:12:55 2008''

Revision as of 04:12, 29 July 2008

Image:1ons.png

Template:STRUCTURE 1ons

Crystal structure of Escherichia coli heat shock protein YedU

Template:ABSTRACT PUBMED 14500888

About this Structure

1ONS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The crystal structure of Escherichia coli heat shock protein YedU reveals three potential catalytic active sites., Zhao Y, Liu D, Kaluarachchi WD, Bellamy HD, White MA, Fox RO, Protein Sci. 2003 Oct;12(10):2303-11. PMID:14500888

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