2hpd

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{{STRUCTURE_2hpd| PDB=2hpd | SCENE= }}
{{STRUCTURE_2hpd| PDB=2hpd | SCENE= }}
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'''CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S'''
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===CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S===
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==Overview==
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Cytochrome P450BM-3, a bacterial fatty acid monoxygenase, resembles the eukaryotic microsomal P450's and their flavoprotein reductase in primary structure and function. The three-dimensional structure of the hemoprotein domain of P450BM-3 was determined by x-ray diffraction and refined to an R factor of 16.9 percent at 2.0 angstrom resolution. The structure consists of an alph and a beta domain. The active site heme is accessible through a long hydrophobic channel formed primarily by the beta domain and the B' and F helices of the alpha domain. The two molecules in the asymmetric unit differ in conformation around the substrate binding pocket. Substantial differences between P450BM-3 and P450cam, the only other P450 structure available, are observed around the substrate binding pocket and the regions important for redox partner binding. A general mechanism for proton transfer in P450's is also proposed.
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{{ABSTRACT_PUBMED_8342039}}
==About this Structure==
==About this Structure==
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[[Category: Peterson, J A.]]
[[Category: Peterson, J A.]]
[[Category: Ravichandran, K G.]]
[[Category: Ravichandran, K G.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:32:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:14:54 2008''

Revision as of 04:14, 29 July 2008

Image:2hpd.png

Template:STRUCTURE 2hpd

CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S

Template:ABSTRACT PUBMED 8342039

About this Structure

2HPD is a Single protein structure of sequence from Bacillus megaterium. Full crystallographic information is available from OCA.

Reference

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's., Ravichandran KG, Boddupalli SS, Hasermann CA, Peterson JA, Deisenhofer J, Science. 1993 Aug 6;261(5122):731-6. PMID:8342039

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