2grl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2grl.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2grl.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2grl| PDB=2grl | SCENE= }}
{{STRUCTURE_2grl| PDB=2grl | SCENE= }}
-
'''Crystal structure of dCT/iCF10 complex'''
+
===Crystal structure of dCT/iCF10 complex===
-
==Overview==
+
<!--
-
In many bacteria expression of lateral gene transfer and of virulence factors is controlled by cell-cell signalling systems. Molecular interactions of microbial signal molecules with their cognate receptors are not well understood. For the Enterococcus faecalis conjugative plasmid pCF10, the PrgX protein serves as a molecular switch controlling expression of conjugation and virulence genes encoded by the plasmid. The induction state of a pCF10-carrying donor cell is determined by the ratio of two signalling peptides, cCF10 pheromone and iCF10 inhibitor. Recent analysis of PrgX/cCF10 interactions suggests a mechanism for conversion to the induced state. However, the means by which iCF10 peptide antagonizes cCF10 activity is unclear, and it has been suggested that inhibitor peptides block import of pheromone peptides. We now show that both of these peptides interact with the same binding pocket of PrgX, but they differentially alter the conformation of the protein and its oligomerization state, resulting in opposing biological activities.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17038121}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17038121 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17038121}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Receptor]]
[[Category: Receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:26:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:22:24 2008''

Revision as of 04:22, 29 July 2008

Image:2grl.png

Template:STRUCTURE 2grl

Crystal structure of dCT/iCF10 complex

Template:ABSTRACT PUBMED 17038121

About this Structure

2GRL is a Single protein structure of sequence from Enterococcus faecalis. Full crystallographic information is available from OCA.

Reference

Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides., Kozlowicz BK, Shi K, Gu ZY, Ohlendorf DH, Earhart CA, Dunny GM, Mol Microbiol. 2006 Nov;62(4):958-69. Epub 2006 Oct 13. PMID:17038121

Page seeded by OCA on Tue Jul 29 07:22:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2grl"
Personal tools