2o61

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[[Image:2o61.gif|left|200px]]
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{{Seed}}
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[[Image:2o61.png|left|200px]]
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{{STRUCTURE_2o61| PDB=2o61 | SCENE= }}
{{STRUCTURE_2o61| PDB=2o61 | SCENE= }}
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'''Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer'''
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===Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer===
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==Overview==
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Transcriptional activation of the interferon-beta (IFN-beta) gene requires assembly of an enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFkappaB. These factors bind cooperatively to the IFN-beta enhancer and recruit coactivators and chromatin-remodeling proteins to the IFN-beta promoter. We describe here a crystal structure of the DNA-binding domains of IRF-3, IRF-7, and NFkappaB, bound to one half of the enhancer, and use a previously described structure of the remaining half to assemble a complete picture of enhanceosome architecture in the vicinity of the DNA. Association of eight proteins with the enhancer creates a continuous surface for recognizing a composite DNA-binding element. Paucity of local protein-protein contacts suggests that cooperative occupancy of the enhancer comes from both binding-induced changes in DNA conformation and interactions with additional components such as CBP. Contacts with virtually every nucleotide pair account for the evolutionary invariance of the enhancer sequence.
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The line below this paragraph, {{ABSTRACT_PUBMED_17574024}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17574024 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17574024}}
==About this Structure==
==About this Structure==
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[[Category: Panne, D.]]
[[Category: Panne, D.]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:22:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:22:50 2008''

Revision as of 04:22, 29 July 2008

Image:2o61.png

Template:STRUCTURE 2o61

Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer

Template:ABSTRACT PUBMED 17574024

About this Structure

2O61 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

An atomic model of the interferon-beta enhanceosome., Panne D, Maniatis T, Harrison SC, Cell. 2007 Jun 15;129(6):1111-23. PMID:17574024

Page seeded by OCA on Tue Jul 29 07:22:50 2008

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