2o6n

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[[Image:2o6n.jpg|left|200px]]
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{{Seed}}
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[[Image:2o6n.png|left|200px]]
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{{STRUCTURE_2o6n| PDB=2o6n | SCENE= }}
{{STRUCTURE_2o6n| PDB=2o6n | SCENE= }}
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'''RH4B: designed right-handed coiled coil tetramer with all biological amino acids'''
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===RH4B: designed right-handed coiled coil tetramer with all biological amino acids===
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==Overview==
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The previous design of an unprecedented family of two-, three-, and four-helical, right-handed coiled coils utilized nonbiological amino acids to efficiently pack spaces in the oligomer cores. Here we show that a stable, right-handed parallel tetrameric coiled coil, called RH4B, can be designed entirely using biological amino acids. The X-ray crystal structure of RH4B was determined to 1.1 Angstrom resolution using a designed metal binding site to coordinate a single Yb(2+) ion per 33-amino acid polypeptide chain. The resulting experimental phases were particularly accurate, and the experimental electron density map provided an especially clear, unbiased view of the molecule. The RH4B structure closely matched the design, with equivalent core rotamers and an overall root-mean-square deviation for the N-terminal repeat of the tetramer of 0.24 Angstrom. The clarity and resolution of the electron density map, however, revealed alternate rotamers and structural differences between the three sequence repeats in the molecule. These results suggest that the RH4B structure populates an unanticipated variety of structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_17766380}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17766380 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17766380}}
==About this Structure==
==About this Structure==
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[[Category: Right-handed]]
[[Category: Right-handed]]
[[Category: Tetramer]]
[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:23:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:27:44 2008''

Revision as of 04:27, 29 July 2008

Image:2o6n.png

Template:STRUCTURE 2o6n

RH4B: designed right-handed coiled coil tetramer with all biological amino acids

Template:ABSTRACT PUBMED 17766380

About this Structure

2O6N is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structure of a designed, right-handed coiled-coil tetramer containing all biological amino acids., Sales M, Plecs JJ, Holton JM, Alber T, Protein Sci. 2007 Oct;16(10):2224-32. Epub 2007 Aug 31. PMID:17766380

Page seeded by OCA on Tue Jul 29 07:27:44 2008

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