1nlm

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{{STRUCTURE_1nlm| PDB=1nlm | SCENE= }}
{{STRUCTURE_1nlm| PDB=1nlm | SCENE= }}
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'''CRYSTAL STRUCTURE OF MURG:GLCNAC COMPLEX'''
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===CRYSTAL STRUCTURE OF MURG:GLCNAC COMPLEX===
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==Overview==
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MurG is an essential glycosyltransferase that forms the glycosidic linkage between N-acetyl muramyl pentapeptide and N-acetyl glucosamine in the biosynthesis of the bacterial cell wall. This enzyme is a member of a major superfamily of NDP-glycosyltransferases for which no x-ray structures containing intact substrates have been reported. Here we present the 2.5-A crystal structure of Escherichia coli MurG in complex with its donor substrate, UDP-GlcNAc. Combined with genomic analysis of other superfamily members and site-specific mutagenesis of E. coli MurG, this structure sheds light on the molecular basis for both donor and acceptor selectivity for the superfamily. This structural analysis suggests that it will be possible to evolve new glycosyltransferases from prototypical superfamily members by varying two key loops while maintaining the overall architecture of the family and preserving key residues.
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(as it appears on PubMed at http://www.pubmed.gov), where 12538870 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12538870}}
==About this Structure==
==About this Structure==
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[[Category: Walker, S.]]
[[Category: Walker, S.]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:40:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:28:13 2008''

Revision as of 04:28, 29 July 2008

Image:1nlm.png

Template:STRUCTURE 1nlm

CRYSTAL STRUCTURE OF MURG:GLCNAC COMPLEX

Template:ABSTRACT PUBMED 12538870

About this Structure

1NLM is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases., Hu Y, Chen L, Ha S, Gross B, Falcone B, Walker D, Mokhtarzadeh M, Walker S, Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):845-9. Epub 2003 Jan 21. PMID:12538870

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