2f1g

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{{STRUCTURE_2f1g| PDB=2f1g | SCENE= }}
{{STRUCTURE_2f1g| PDB=2f1g | SCENE= }}
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'''Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide'''
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===Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide===
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==Overview==
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A series of N(alpha)-2-benzoxazolyl-alpha-amino acid-(arylaminoethyl)amides were identified as potent, selective, and noncovalent inhibitors of cathepsin S. Structure-activity relationships including strategies for modulating the selectivities among cathepsins S, K, and L, and in vivo pharmacokinetics are discussed. A X-ray structure of compound 3 bound to the active site of cathepsin S is also reported.
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(as it appears on PubMed at http://www.pubmed.gov), where 16446091 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16446091}}
==About this Structure==
==About this Structure==
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[[Category: Inhibition]]
[[Category: Inhibition]]
[[Category: Noncovalent]]
[[Category: Noncovalent]]
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Revision as of 04:30, 29 July 2008

Image:2f1g.png

Template:STRUCTURE 2f1g

Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide

Template:ABSTRACT PUBMED 16446091

About this Structure

2F1G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3., Tully DC, Liu H, Alper PB, Chatterjee AK, Epple R, Roberts MJ, Williams JA, Nguyen KT, Woodmansee DH, Tumanut C, Li J, Spraggon G, Chang J, Tuntland T, Harris JL, Karanewsky DS, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1975-80. Epub 2006 Jan 30. PMID:16446091

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