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2hcc

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[[Image:2hcc.gif|left|200px]]
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[[Image:2hcc.png|left|200px]]
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{{STRUCTURE_2hcc| PDB=2hcc | SCENE= }}
{{STRUCTURE_2hcc| PDB=2hcc | SCENE= }}
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'''SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE HCC-2, NMR, 30 STRUCTURES'''
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===SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE HCC-2, NMR, 30 STRUCTURES===
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==Overview==
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HCC-2, a 66-amino acid residue human CC chemokine, was reported to induce chemotaxis on monocytes, T-lymphocytes, and eosinophils. The three-dimensional structure of HCC-2 has been determined by 1H nuclear magnetic resonance (NMR) spectroscopy and restrained molecular dynamics calculations on the basis of 871 experimental restraints. The structure is well-defined, exhibiting average root-mean-square deviations of 0.58 and 0.96 A for the backbone heavy atoms and all heavy atoms of residues 5-63, respectively. In contrast to most other chemokines, subtle structural differences impede dimer formation of HCC-2 in a concentration range of 0.1 microM to 2 mM. HCC-2, however, exhibits the same structural elements as the other chemokines, i.e., a triple-stranded antiparallel beta-sheet covered by an alpha-helix, showing that the chemokine fold is not influenced by quaternary interactions. Structural investigations with a HCC-2 mutant prove that a third additional disulfide bond present in wild-type HCC-2 is not necessary for maintaining the relative orientation of the helix and the beta-sheet.
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(as it appears on PubMed at http://www.pubmed.gov), where 10320325 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10320325}}
==About this Structure==
==About this Structure==
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2HCC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCC OCA].
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2HCC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCC OCA].
==Reference==
==Reference==
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[[Category: Mip-5]]
[[Category: Mip-5]]
[[Category: Nmr structure]]
[[Category: Nmr structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:07:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:31:30 2008''

Revision as of 04:31, 29 July 2008

Image:2hcc.png

Template:STRUCTURE 2hcc

SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE HCC-2, NMR, 30 STRUCTURES

Template:ABSTRACT PUBMED 10320325

About this Structure

2HCC is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype., Sticht H, Escher SE, Schweimer K, Forssmann WG, Rosch P, Adermann K, Biochemistry. 1999 May 11;38(19):5995-6002. PMID:10320325

Page seeded by OCA on Tue Jul 29 07:31:30 2008

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