3crm

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{{STRUCTURE_3crm| PDB=3crm | SCENE= }}
{{STRUCTURE_3crm| PDB=3crm | SCENE= }}
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'''Structure of tRNA Dimethylallyltransferase: RNA Modification through a Channel'''
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===Structure of tRNA Dimethylallyltransferase: RNA Modification through a Channel===
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==Overview==
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Dimethylallyltransferase (DMATase) transfers a five-carbon isoprenoid moiety from dimethylallyl pyrophosphate (DMAPP) to the amino group of adenosine at position 37 of certain tRNAs. Reported here are the crystal structures of Pseudomonas aeruginosa DMATase alone and in complex with pyrophosphate at 1.9 A resolution. Surprisingly, the enzyme possesses a central channel spanning the entire width of the enzyme. Both the accepting substrate tRNA and the donating substrate DMAPP appear to enter the channel from opposite sides in an ordered sequence, with tRNA first and DMAPP second, and the RNA modification reaction occurs in the middle of the channel once the two substrates have met. The structure of DMATase is homologous to a class of small soluble kinases involved in biosynthesis of nucleotide precursors for nucleic acids, indicating its possibly evolutionary origin. Furthermore, specific recognition of the pyrophosphate by a conserved loop in DMATase, similar to the P-loop commonly seen in diverse nucleotide-binding proteins, demonstrates that DMATase is structurally and mechanistically distinct from farnesyltransferase, another family of prenyltransferases involved in protein modification.
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==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Trna processing]]
[[Category: Trna processing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:44:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:39:08 2008''

Revision as of 04:39, 29 July 2008

Image:3crm.png

Template:STRUCTURE 3crm

Structure of tRNA Dimethylallyltransferase: RNA Modification through a Channel

Template:ABSTRACT PUBMED 17292915

About this Structure

3CRM is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structure of tRNA dimethylallyltransferase: RNA modification through a channel., Xie W, Zhou C, Huang RH, J Mol Biol. 2007 Mar 30;367(3):872-81. Epub 2007 Jan 24. PMID:17292915

Page seeded by OCA on Tue Jul 29 07:39:08 2008

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