2o97

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{{STRUCTURE_2o97| PDB=2o97 | SCENE= }}
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'''Crystal Structure of E. coli HU heterodimer'''
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===Crystal Structure of E. coli HU heterodimer===
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==Overview==
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We determined the crystal structure of the Escherichia coli nucleoid-associated HUalphabeta protein by x-ray diffraction and observed that the heterodimers form multimers with octameric units in three potential arrangements, which may serve specialized roles in different DNA transaction reactions. It is of special importance that one of the structures forms spiral filaments with left-handed rotations. A negatively superhelical DNA can be modeled to wrap around this left-handed HUalphabeta multimer. Whereas the wild-type HU generated negative DNA supercoiling in vitro, an engineered heterodimer with an altered amino acid residue critical for the formation of the left-handed spiral protein in the crystal was defective in the process, thus providing the structural explanation for the classical property of HU to restrain negative supercoils in DNA.
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{{ABSTRACT_PUBMED_17360520}}
==About this Structure==
==About this Structure==
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[[Category: E. coli]]
[[Category: E. coli]]
[[Category: Heterodimer]]
[[Category: Heterodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:40:40 2008''

Revision as of 04:40, 29 July 2008

Image:2o97.png

Template:STRUCTURE 2o97

Crystal Structure of E. coli HU heterodimer

Template:ABSTRACT PUBMED 17360520

About this Structure

2O97 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Spiral structure of Escherichia coli HUalphabeta provides foundation for DNA supercoiling., Guo F, Adhya S, Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4309-14. Epub 2007 Mar 5. PMID:17360520

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