1yg9

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[[Image:1yg9.gif|left|200px]]
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{{STRUCTURE_1yg9| PDB=1yg9 | SCENE= }}
{{STRUCTURE_1yg9| PDB=1yg9 | SCENE= }}
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'''The structure of mutant (N93Q) of bla g 2'''
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===The structure of mutant (N93Q) of bla g 2===
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==Overview==
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The crystal structure of Bla g 2 was solved in order to investigate the structural basis for the allergenic properties of this unusual protein. This is the first structure of an aspartic protease in which conserved glycine residues, in two canonical DTG triads, are substituted by different amino acid residues. Another unprecedented feature revealed by the structure is the single phenylalanine residue insertion on the tip of the flap, with the side-chain occupying the S1 binding pocket. This and other important amino acid substitutions in the active site region of Bla g 2 modify the interactions in the vicinity of the catalytic aspartate residues, increasing the distance between them to approximately 4A and establishing unique direct contacts between the flap and the catalytic residues. We attribute the absence of substantial catalytic activity in Bla g 2 to these unusual features of the active site. Five disulfide bridges and a Zn-binding site confer stability to the protein, which may contribute to sensitization at lower levels of exposure than other allergens.
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(as it appears on PubMed at http://www.pubmed.gov), where 15811379 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15811379}}
==About this Structure==
==About this Structure==
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[[Category: Allegren]]
[[Category: Allegren]]
[[Category: Bla g 2]]
[[Category: Bla g 2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:16:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:42:40 2008''

Revision as of 04:42, 29 July 2008

Image:1yg9.png

Template:STRUCTURE 1yg9

The structure of mutant (N93Q) of bla g 2

Template:ABSTRACT PUBMED 15811379

About this Structure

1YG9 is a Single protein structure of sequence from Blattella germanica. Full crystallographic information is available from OCA.

Reference

Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition., Gustchina A, Li M, Wunschmann S, Chapman MD, Pomes A, Wlodawer A, J Mol Biol. 2005 Apr 29;348(2):433-44. PMID:15811379

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