2nsn

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{{STRUCTURE_2nsn| PDB=2nsn | SCENE= }}
{{STRUCTURE_2nsn| PDB=2nsn | SCENE= }}
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'''Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1'''
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===Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1===
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==Overview==
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Nod-like receptors (NLRs), Nod1 and Nod2 are cytosolic detectors of pathogen-associated molecular patterns (PAMPs). Nod1 is a three-domain protein, consisting of a caspase activation and recruitment domain (CARD), a nucleotide-binding oligomerization domain (NOD), and a leucine-rich repeat domain (LRR). The binding of PAMPs to the LRR results in the activation of signaling through homophilic CARD-CARD interactions. Several CARD structures have been determined, including a recent NMR structure of Nod1 CARD. In contrast to the reported NMR structure, the crystal structure reported here is a dimer, where the sixth helix is swapped between two monomers. While the overall structure is very similar to the known CARD structures, this is the first report of a homodimeric CARD structure. The ability of the CARD to exist in monomeric and dimeric forms suggests another level of regulation in the activation of NLR proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17173864 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17173864}}
==About this Structure==
==About this Structure==
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[[Category: Ramaswamy, S.]]
[[Category: Ramaswamy, S.]]
[[Category: Six helix greek key motif]]
[[Category: Six helix greek key motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:51:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:44:23 2008''

Revision as of 04:44, 29 July 2008

Image:2nsn.png

Template:STRUCTURE 2nsn

Crystal structure of Caspace Activation and Recruitment Domain (CARD) of NOD1

Template:ABSTRACT PUBMED 17173864

About this Structure

2NSN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Nod1 caspase activation and recruitment domain., Coussens NP, Mowers JC, McDonald C, Nunez G, Ramaswamy S, Biochem Biophys Res Commun. 2007 Feb 2;353(1):1-5. Epub 2006 Dec 6. PMID:17173864

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