1pid
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(New page: 200px<br /><applet load="1pid" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pid, resolution 1.3Å" /> '''BOVINE DESPENTAPEPTID...)
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Revision as of 21:42, 20 November 2007
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BOVINE DESPENTAPEPTIDE INSULIN
Overview
The crystal structure of despentapeptide insulin, a monomeric insulin, has, been refined at 1.3 A spacing and subsequently used to predict and model, the organization in the insulin fibril. The model makes use of the, contacts in the densely packed despentapeptide insulin crystal, and takes, into account other experimental evidence, including binding studies with, Congo red. The dimensions of this model fibril correspond well with those, measured experimentally, and the monomer-monomer contacts within the, fibril are in accordance with the known physical chemistry of insulin, fibrils. Using this model, it may be possible to predict mutations in, insulin that might alleviate problems associated with fibril formation, during insulin therapy.
About this Structure
1PID is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
Reference
A model of insulin fibrils derived from the x-ray crystal structure of a monomeric insulin (despentapeptide insulin)., Brange J, Dodson GG, Edwards DJ, Holden PH, Whittingham JL, Proteins. 1997 Apr;27(4):507-16. PMID:9141131
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