1rsf

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{{STRUCTURE_1rsf| PDB=1rsf | SCENE= }}
{{STRUCTURE_1rsf| PDB=1rsf | SCENE= }}
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'''NMR Structure of Monomeric CAR d1 domain'''
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===NMR Structure of Monomeric CAR d1 domain===
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==Overview==
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The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus B (CVB) and adenovirus (Ad). The normal cellular function of CAR, which is expressed in a wide variety of tissue types, is thought to involve homophilic cell adhesion in the developing brain. The extracellular domain of CAR consists of two immunoglobulin (Ig) domains termed CAR-D1 and CAR-D2. CAR-D1 is shown by sedimentation velocity to be monomeric at pH 3.0. The solution structure and the dynamic properties of monomeric CAR-D1 have been determined by NMR spectroscopy at pH 3.0. The determinants of the CAR-D1 monomer-dimer equilibrium, as well as the binding site of CVB and Ad on CAR, are discussed in light of the monomer structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 14967025 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14967025}}
==About this Structure==
==About this Structure==
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1RSF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSF OCA].
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1RSF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSF OCA].
==Reference==
==Reference==
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[[Category: Coxsackievirus]]
[[Category: Coxsackievirus]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:51:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:48:01 2008''

Revision as of 04:48, 29 July 2008

Image:1rsf.png

Template:STRUCTURE 1rsf

NMR Structure of Monomeric CAR d1 domain

Template:ABSTRACT PUBMED 14967025

About this Structure

1RSF is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the coxsackievirus and adenovirus receptor domain 1., Jiang S, Jacobs A, Laue TM, Caffrey M, Biochemistry. 2004 Feb 24;43(7):1847-53. PMID:14967025

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