2bbj

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{{STRUCTURE_2bbj| PDB=2bbj | SCENE= }}
{{STRUCTURE_2bbj| PDB=2bbj | SCENE= }}
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'''Crystal structure of the CorA Mg2+ transporter'''
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===Crystal structure of the CorA Mg2+ transporter===
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==Overview==
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The magnesium ion, Mg2+, is essential for myriad biochemical processes and remains the only major biological ion whose transport mechanisms remain unknown. The CorA family of magnesium transporters is the primary Mg2+ uptake system of most prokaryotes and a functional homologue of the eukaryotic mitochondrial magnesium transporter. Here we determine crystal structures of the full-length Thermotoga maritima CorA in an apparent closed state and its isolated cytoplasmic domain at 3.9 A and 1.85 A resolution, respectively. The transporter is a funnel-shaped homopentamer with two transmembrane helices per monomer. The channel is formed by an inner group of five helices and putatively gated by bulky hydrophobic residues. The large cytoplasmic domain forms a funnel whose wide mouth points into the cell and whose walls are formed by five long helices that are extensions of the transmembrane helices. The cytoplasmic neck of the pore is surrounded, on the outside of the funnel, by a ring of highly conserved positively charged residues. Two negatively charged helices in the cytoplasmic domain extend back towards the membrane on the outside of the funnel and abut the ring of positive charge. An apparent Mg2+ ion was bound between monomers at a conserved site in the cytoplasmic domain, suggesting a mechanism to link gating of the pore to the intracellular concentration of Mg2+.
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{{ABSTRACT_PUBMED_16598263}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomics consortium]]
[[Category: Structural genomics consortium]]
[[Category: Transporter]]
[[Category: Transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:04:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:52:00 2008''

Revision as of 04:52, 29 July 2008

Image:2bbj.png

Template:STRUCTURE 2bbj

Crystal structure of the CorA Mg2+ transporter

Template:ABSTRACT PUBMED 16598263

About this Structure

2BBJ is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of the CorA Mg2+ transporter., Lunin VV, Dobrovetsky E, Khutoreskaya G, Zhang R, Joachimiak A, Doyle DA, Bochkarev A, Maguire ME, Edwards AM, Koth CM, Nature. 2006 Apr 6;440(7085):833-7. PMID:16598263

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